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Picoanalysis: Picoanalysis of Drugs in Biofluids with Quantitative Label‐Free Surface‐Enhanced Raman Spectroscopy (Small 47/2018)
Author(s) -
Turzhitsky Vladimir,
Zhang Lei,
Horowitz Gary L.,
Vitkin Edward,
Khan Umar,
Zakharov Yuri,
Qiu Le,
Itzkan Irving,
Perelman Lev T.
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870227
Subject(s) - surface enhanced raman spectroscopy , raman spectroscopy , surface plasmon resonance , nanoclusters , materials science , spectroscopy , drug detection , molecule , small molecule , resonance raman spectroscopy , plasmon , analytical chemistry (journal) , raman scattering , nanotechnology , chemistry , optoelectronics , nanoparticle , optics , chromatography , organic chemistry , biochemistry , physics , quantum mechanics
In article number 1802392 , Lev T. Perelman and co‐workers report a quantitative label‐free surface‐enhanced Raman spectroscopy (SERS) method for identifying and quantifying drugs at ultralow concentrations. Self‐assembled gold nanoclusters entrap drug molecules and laser light excites the surface plasmon resonance, yielding a large SERS signal from the molecule trapped near the hot spot, allowing measurements of drugs in urine samples at clinically relevant concentrations.