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Protein Coronas: Beyond Global Charge: Role of Amine Bulkiness and Protein Fingerprint on Nanoparticle–Cell Interaction (Small 46/2018)
Author(s) -
Burnand David,
Milosevic Ana,
Balog Sandor,
SpuchCalvar Miguel,
RothenRutishauser Barbara,
Dengjel Jörn,
Kinnear Calum,
Moore Thomas L.,
PetriFink Alke
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870213
Subject(s) - nanoparticle , amine gas treating , chemistry , corona (planetary geology) , nanotechnology , biophysics , materials science , organic chemistry , physics , biology , astrobiology , venus
Nanoparticle surface chemistry is a key component for nanoparticle‐cell interactions. Positively charged amines are hypothesized to drive these via Coulombic interactions with a negatively charged cell membrane. In article number 1802088 , Calum Kinnear, Thomas L. Moore, Alke Petri‐Fink, and co‐workers report that the degree of amine methylation (i.e. amine bulkiness) is critical in mediating the nanoparticle‐cell interaction via the protein corona.