Premium
Glioma Therapy: Combination Glioma Therapy Mediated by a Dual‐Targeted Delivery System Constructed Using OMCN–PEG–Pep22/DOX (Small 42/2018)
Author(s) -
Qian Wenbo,
Qian Min,
Wang Yi,
Huang Jianfei,
Chen Jian,
Ni Lanchun,
Huang Qingfeng,
Liu Qianqian,
Gong Peipei,
Hou Shiqiang,
Zhu Hui,
Jia Zhongzheng,
Shen Dandan,
Zhu Changlai,
Jiang Rui,
Sun Junlong,
Yao Junzhong,
Tang Zhongyu,
Ji Xiang,
Shi Jinlong,
Huang Rongqin,
Shi Wei
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870192
Subject(s) - glioma , photothermal therapy , drug delivery , targeted drug delivery , cancer research , drug , medicine , pharmacology , materials science , nanotechnology
In article number 1801905 , Jinlong Shi, Rongqin Huang, Wei Shi, and co‐workers describe a novel drug‐loaded system, OPPD, which uses PEG and OMCN linked to the Pep22 polypeptide targeting the low‐density lipoprotein receptor, that can effectively cross the blood‐brain barrier and target glioma cells, exerting an outstanding therapeutic efficacy via both the near‐infrared photothermal and chemotherapeutic effects of the loaded DOX. The collective findings support the utility of OPPD, a promising drug‐delivery vehicle, for future clinical application in glioma therapy.