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Microgels: SERS‐Active‐Charged Microgels for Size‐ and Charge‐Selective Molecular Analysis of Complex Biological Samples (Small 40/2018)
Author(s) -
Kim Dong Jae,
Park SungGyu,
Kim DongHo,
Kim ShinHyun
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870183
Subject(s) - raman spectroscopy , colloidal gold , raman scattering , nanoparticle , nanotechnology , materials science , chemistry , chemical engineering , physics , engineering , optics
In article number 1802520 , Dong‐Ho Kim, Shin‐Hyun Kim, and co‐workers design charged microgels to encapsulate agglomerates of gold nanoparticles for the direct analysis of biological samples through Raman analysis. The charged microgels concentrate oppositely charged small molecules while excluding large proteins, increasing Raman intensity and preventing gold contamination. Using the microgels, fipronil sulfone, a metabolite of a toxic insecticide dissolved in eggs, is directly detected without any sample pretreatment.