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Insulin Delivery Platforms: Multiresponsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery (Small 38/2018)
Author(s) -
Zuo Minzan,
Qian Weirui,
Xu Zuqiang,
Shao Wei,
Hu XiaoYu,
Zhang Dongmei,
Jiang Juli,
Sun Xiaoqiang,
Wang Leyong
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870176
Subject(s) - insulin delivery , insulin , supramolecular chemistry , pillar , chemistry , delivery system , nanotechnology , combinatorial chemistry , materials science , pharmacology , medicine , diabetes mellitus , endocrinology , type 1 diabetes , organic chemistry , engineering , molecule , structural engineering
In article number 1801942 , Xiao‐Yu Hu, Dongmei Zhang, Juli Jiang, Leyong Wang, and co‐workers develop a closed–loop insulin delivery platform based on a supramolecular strategy. Insulin can be transported to the blood vessel through this multiple stimuli‐responsive system. Under hyperglycemic conditions, the in situ generated H 2 O 2 and acidic microenvironment leads to the efficient release of insulin.