Premium
Influenza Nanovaccines: Intranasal Nanovaccine Confers Homo‐ and Hetero‐Subtypic Influenza Protection (Small 13/2018)
Author(s) -
Qi Mi,
Zhang XianEn,
Sun Xianxun,
Zhang Xiaowei,
Yao Yanfeng,
Liu Siling,
Chen Ze,
Li Wei,
Zhang Zhiping,
Chen Jianjun,
Cui Zongqiang
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870056
Subject(s) - nasal administration , virology , vaccination , recombinant dna , antigen , virus , biology , immunology , gene , genetics
In article number 1703207 , Jianjun Chen, Zongqiang Cui, and co‐workers develop an intranasal nanovaccine which provides protection against homo‐ and heterosubtypic influenza. The 3M 2e‐rHF nanovaccine is constructed by displaying three‐sequential repeats of the influenza conserved antigen M2e on the self‐assembling recombinant human heavy chain ferritin (rHF) cage. Intranasal vaccination with 3M2e‐rHF in the absence of adjuvants confers complete protection against a lethal infection of homosubtypic H1N1 and heterosubtypic H9N2 virus.