Premium
Cancer Diagnosis: A Universal Upconversion Sensing Platform for the Sensitive Detection of Tumour‐Related ncRNA through an Exo III‐Assisted Cycling Amplification Strategy (Small 10/2018)
Author(s) -
Zhang Keying,
Yang Lin,
Lu Feng,
Wu Xingcai,
Zhu JunJie
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201870044
Subject(s) - exonuclease iii , photon upconversion , microrna , cancer research , dna , rna , nanotechnology , materials science , chemistry , microbiology and biotechnology , computer science , biology , optoelectronics , gene , biochemistry , luminescence , escherichia coli
In article number 1703858 , Xingcai Wu, Jun‐Jie Zhu, and co‐workers report a universal and sensitive upconversion sensing nanoplatform for detecting tumor‐related non‐coding RNA. The sensitivity of the probe is improved by tuning the number of DNA units on the gold nanoparticles, and an exonuclease III‐assisted target cycling amplification strategy improves the sensitivity and achieves the universality of this sensing nanoplatform. Through this method, the expression level of microRNA‐21 in human breast cancer cell lysate is successfully measured, suggesting its potential in cancer diagnosis.