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Self‐Assembly of Microparticles by Supramolecular Homopolymerization of One Component DNA Molecule
Author(s) -
Zeng Jie,
Fu Wenhao,
Qi Zhenping,
Zhu Qiushuang,
He Huawei,
Huang Chengzhi,
Zuo Hua,
Mao Chengde
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201805552
Subject(s) - dna , dna nanotechnology , self assembly , supramolecular chemistry , nanotechnology , nucleic acid , molecule , materials science , chemistry , biophysics , biology , biochemistry , organic chemistry
DNA is a superb molecule for self‐assembly of nanostructures. Often many DNA strands are required for the assembly of one DNA nanostructure. For lowering the cost of synthesizing DNA strands and facilitating the assembly process, it is highly desirable to use a minimal number of unique strands for potential technological applications. Herein, a strategy is reported to assemble a series of DNA microparticles (DNAµPs) from one component DNA strand. As a demonstration of the application of the resulting DNAµPs, the design and assembled DNAµPs are modified to carry additional single‐stranded tails on their surfaces. The modified DNAµPs can either capture other nucleic acids or display CpG motifs to stimulate immune responses.