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A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures
Author(s) -
Kizer Megan E.,
Linhardt Robert J.,
Chandrasekaran Arun Richard,
Wang Xing
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201805386
Subject(s) - hero , nanotechnology , dna , dna origami , dna nanotechnology , nanostructure , nanoscopic scale , materials science , computer science , chemistry , artificial intelligence , biochemistry
Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA‐based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed “properties” and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Like a hero, DNA nanostructures have the ability to put on a suit equipped with honing mechanisms, molecular flares, encapsulated cargoes, a protective body armor, and an evasive stealth mode.