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Real‐Time Mapping of Ultratrace Singlet Oxygen in Rat during Acute and Chronic Inflammations via a Chemiluminescent Nanosensor
Author(s) -
Zhang Shenghai,
Cui Hongbo,
Gu Min,
Zhao Na,
Cheng Mengqi,
Lv Jiagen
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201804662
Subject(s) - nanosensor , singlet oxygen , chemiluminescence , reactive oxygen species , quenching (fluorescence) , oxygen , intramolecular force , energy transfer , chemistry , photochemistry , oxygen sensor , nanotechnology , materials science , fluorescence , biophysics , stereochemistry , chemical physics , biology , biochemistry , physics , organic chemistry , quantum mechanics
Sensing nonradiation‐induced singlet oxygen ( 1 O 2 ) in whole‐animal is deemed as one of the most challenging tasks in noninvasive techniques due to the µs level lifetime of 1 O 2 and quenching by numerous reductants in tissues. Here a distinct chemiluminescent (CL) nanosensor (NTPE‐PH) that boasts ultrahigh concentrated CL units in one nanoparticle is reported. Taking advantage of the intramolecular energy transfer mechanism that promises high energy transfer efficiency and the aggregation‐induced emission behavior that guarantees high CL amplification, the NTPE‐PH sensor is sensitive to a n m level 1 O 2 . Experiments demonstrate that the NTPE‐PH yields a highly selective CL response toward 1 O 2 among common reactive oxygen species. With proved low cytotoxicity and good animal compatibility, real‐time mapping of ultratrace 1 O 2 in whole‐animal during acute and chronic inflammations is first achieved. It is anticipated that the NTPE‐PH sensor can be a useful tool for monitoring 1 O 2 variation during immune response and pathological processes corresponding to different stimuli, even with drug treatment included.