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From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor‐Targeting Nanocarriers Based on Host–Guest Interaction between a Pillar[5]arene‐Based Prodrug and a RGD‐Sulfonate Guest
Author(s) -
Hu XiaoYu,
Gao Lei,
Mosel Stefanie,
Ehlers Martin,
Zellermann Elio,
Jiang Hao,
Knauer Shirley K.,
Wang Leyong,
Schmuck Carsten
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201803952
Subject(s) - nanocarriers , prodrug , supramolecular chemistry , micelle , amphiphile , drug delivery , chemistry , doxorubicin , in vivo , drug carrier , vesicle , biophysics , materials science , nanotechnology , combinatorial chemistry , copolymer , biochemistry , organic chemistry , membrane , aqueous solution , medicine , molecule , chemotherapy , biology , surgery , microbiology and biotechnology , polymer
The targeting ability, drug‐loading capacity, and size of the drug nanocarriers are crucial for enhancing the therapeutic index for cancer therapy. Herein, the morphology and size‐controllable fabrication of supramolecular tumor‐targeting nanocarriers based on host–guest recognition between a novel pillar[5]arene‐based prodrug WP5‐DOX and a Arg‐Gly‐Asp (RGD)‐modified sulfonate guest RGD‐SG is reported. The amphiphilic WP5‐DOX ⊃ RGD‐SG complex with a molar ratio of 5:1 self‐assembles into vesicles, whereas smaller‐sized micelles can be obtained by changing the molar ratio to 1:3. This represents a novel strategy of controllable construction of supramolecular nanovehicles with different sizes and morphologies based on the same host−guest interactions by using different host−guest ratios. Furthermore, in vitro and in vivo studies reveal that both these prodrug nanocarriers could selectively deliver doxorubicin to RGD receptor‐overexpressing cancer cells, leading to longer blood retention time, enhanced antitumor efficacy, and reduced systematic toxicity in murine tumor model, suggesting their potential application for targeted drug delivery.