Premium
Drug‐Controlled Release Based on Complementary Base Pairing Rules for Photodynamic–Photothermal Synergistic Tumor Treatment
Author(s) -
Zhan Qichen,
Shi Xianqing,
Zhou Jiahong,
Zhou Lin,
Wei Shaohua
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201803926
Subject(s) - photothermal therapy , pairing , photosensitizer , base pair , photothermal effect , drug delivery , nanoparticle , reagent , phthalocyanine , thymine , nanotechnology , materials science , chemistry , combinatorial chemistry , photochemistry , dna , biophysics , organic chemistry , physics , biochemistry , biology , superconductivity , quantum mechanics
Controlled drug release systems can enhance the safety and availability but avoid the side effect of drugs. Herein, the concept of DNA complementary base pairing rules in biology is used to design and prepare a photothermal‐triggered drug release system. Adenine (A) modified polydopamine nanoparticles (A‐PDA, photothermal reagent) can effectively bind with thymine (T) modified Zinc phthalocyanine (T‐ZnPc, photosensitizer) forming A‐PDA = T‐ZnPc (PATP) complex based on A = T complementary base pairing rules. Similar to DNA, whose base pairing in double strands will break by heating, T‐ZnPc can be effectively released from A‐PDA after near infrared irradiation–triggered light‐thermal conversion to obtain satisfactory photodynamic–photothermal synergistic tumor treatment. In addition, PDA can carry abundant Gd 3+ to provide magnetic resonance imaging guided delivery and theranostic function.