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In Vivo Chemoselective Photoacoustic Imaging of Copper(II) in Plant and Animal Subjects
Author(s) -
Zeng Leli,
Ma Gongcheng,
Xu Han,
Mu Jing,
Li Fan,
Gao Xiaoting,
Deng Zhuoting,
Qu Junle,
Huang Peng,
Lin Jing
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201803866
Subject(s) - in vivo , photoacoustic imaging in biomedicine , detection limit , absorbance , copper , metal ions in aqueous solution , in vitro , nuclear chemistry , metal , chemistry , materials science , analytical chemistry (journal) , chromatography , biochemistry , biology , optics , organic chemistry , physics , microbiology and biotechnology
The detection of Cu 2+ in living plants and animals is of great importance for environment monitoring and disease diagnosis. Here, a near‐infrared (NIR) turn‐on photoacoustic (PA) probe (denoted as LET‐2) is developed for Cu 2+ detection in living subjects, such as soybean sprouts and mice. The absorbance band of LET‐2 shifts from 625 to 715 nm after the interaction with Cu 2+ , thus producing strong PA signal output at 715 nm (PA 715 ) as an indicator. The PA 715 value is increased as a function of the concentration of Cu 2+ (0 × 10 −6 –20 × 10 −6 m ), with a calculated limit of detection of 10.8 × 10 −9 m . More importantly, both in vitro and in vivo studies in soybean sprouts and mice indicate that the as‐prepared LET‐2 PA probe is highly sensitive and selective for Cu 2+ detection. These findings provide a solution for in vivo detection of metal ions by using chemoselective PA probes.