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Multifunctional Silicon–Carbon Nanohybrids Simultaneously Featuring Bright Fluorescence, High Antibacterial and Wound Healing Activity
Author(s) -
Hu Guyue,
Song Bin,
Jiang Airui,
Chu Binbin,
Shen Xiaobin,
Tang Jiali,
Su Yuanyuan,
He Yao
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201803200
Subject(s) - wound healing , fluorescence , quantum yield , in vivo , materials science , silicon , photoluminescence , aqueous solution , antibacterial activity , nanotechnology , carbon fibers , biomedical engineering , biophysics , chemistry , bacteria , optoelectronics , organic chemistry , surgery , composite material , biology , composite number , medicine , physics , microbiology and biotechnology , genetics , quantum mechanics
In this work, a class of multifunctional silicon–carbon nanohybrids (designated as SiCNs), which simultaneously possess aqueous dispersibility, bright fluorescence (photoluminescence quantum yield [PLQY]: ≈28%), as well as high antibacterial and wound healing activity, is presented. Taking advantage of these unique merits, cell distribution and pharmacological behavior of the SiCNs is first investigated through tracking their strong and stable fluorescence. The high bacteria inhibition ability (≈82.9% killing rate toward S. aureus) and hemostatic effects (shorten the bleeding time from ≈60 to ≈15 s) of the resultant SiCNs are then demonstrated. Moreover, the wound closure promotion activity (10% lead in wound contraction) is systematically demonstrated in vivo, which is especially suitable for wound healing applications. The results suggest the SiCNs as a new kind of high‐performance multifunctional nanoagents suitable for various biological and biomedical utilizations.