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Preparation of Template‐Free Robust Yolk–Shell Gelled Particles from Controllably Evolved All‐in‐Water Emulsions
Author(s) -
Douliez JeanPaul,
Perro Adeline,
Chapel JeanPaul,
Goudeau Bertrand,
Béven Laure
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201803042
Subject(s) - gelatin , polyethylene glycol , peg ratio , emulsion , aqueous solution , materials science , chemical engineering , aqueous two phase system , glutaraldehyde , chemistry , chromatography , organic chemistry , finance , engineering , economics
A template‐free all‐aqueous bulk preparation of robust hollow capsules having a gelatin shell from all‐in‐water double emulsions is reported. The hot (>40 °C) quaternary system water/polyethylene glycol (PEG)/gelatin/alginate is shown to spontaneously form PEG‐in‐gelatin‐in‐PEG double water emulsion droplets having a multinuclear core. These droplets are stable upon cooling below the temperature at which gelatin gelled. In contrast, above the melting temperature of gelatin, multinuclear double emulsion droplets controllably evolve into stable mononuclear yolk (aqueous PEG)‐shell (gelatin) capsules dispersed in the aqueous PEG continuous phase. It is demonstrated that the gelatin shell can accommodate negatively charged latex beads and be re‐enforced by glutaraldehyde or silica. These capsules are also shown to encapsulate payloads, suggesting possible applications in microencapsulation, drug delivery, and synthetic biology.