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Rationally Designed Monodisperse Gd 2 O 3 /Bi 2 S 3 Hybrid Nanodots for Efficient Cancer Theranostics
Author(s) -
Lv Xiaoyan,
Wang Xue,
Li Ting,
Wei Chaogang,
Tang Yong'an,
Yang Tao,
Wang Qiaoli,
Yang Xiangliang,
Chen Huabing,
Shen Junkang,
Yang Hong,
Ke Hengte
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201802904
Subject(s) - nanodot , nanocages , materials science , nanotechnology , dispersity , photothermal therapy , nanoparticle , nanorod , nanomedicine , chemistry , organic chemistry , polymer chemistry , catalysis
Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine. However, a critical challenge remains in the rational fabrication of monodisperse multicomponent nanoparticles with enhanced multifunctional characteristics for efficient cancer theranostics. Here, a rational and facile synthesis of monodisperse Gd 2 O 3 /Bi 2 S 3 hybrid nanodots (Gd/Bi‐NDs) is demonstrated as a multifunctional nanotheranostic agent using a albumin nanoreactor for computed tomography (CT)/photoacoustics (PA)/magnetic resonance (MR) imaging and simultaneous photothermal tumor ablation. Two nanoprecipitation reactions in one albumin nanoreactor are simultaneously conducted to generate ultrasmall Gd/Bi‐NDs with both orthorhombic Bi 2 S 3 and cubic Gd 2 O 3 nanostructures. Their hybrid nanostructure generates distinctly enhanced longitudinal relaxivity in the spatially confined albumin nanocage as compared to monocomponent Gd 2 O 3 nanodots. Moreover, such hybrid nanodots possess multiple desirable characteristics including superior photobleaching resistance, efficient cellular uptake, preferable tumor accumulation, good in vivo clearance, and negligible acute toxicity, thereby leading to complementary PA/CT/MR imaging with spatial and anatomic characteristics, as well as effective photothermal tumor ablation without regrowth. These results represent a promising approach to fabricate monodisperse multicomponent nanotheranostic agents for efficient cancer theranostics.