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Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy
Author(s) -
Fang Yu,
Lian Xizhen,
Huang Yanyan,
Fu Guo,
Xiao Zhifeng,
Wang Qi,
Nan Beiyan,
Pellois JeanPhilippe,
Zhou HongCai
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201802709
Subject(s) - nanobiotechnology , cytoplasm , organelle , cancer cell , compartment (ship) , cell , subcellular localization , nanotechnology , intracellular , microbiology and biotechnology , nanomedicine , cell membrane , nucleus , biophysics , chemistry , cancer , biology , materials science , biochemistry , oceanography , genetics , geology , nanoparticle
Understanding the key factors for successful subcellular compartment targeting for cargo delivery systems is of great interest in a variety of fields such as bionanotechnology, cell biology, and nanotherapies. However, the fundamental basis for intracellular transportation with these systems has thus far rarely been discussed. As a cargo vector, porous coordination cages (PCCs) have great potential for use in cancer nanotherapy and to elucidate fundamental insight regarding subcellular compartment targeting. Herein, it is shown that the transportation of PCC cargo vectors though various subcellular barriers of the mammalian cell can be manipulated by tuning the vector's electronic property and surface affinity. It is found that the PCCs become selectively aggregated at the cell membrane, the cytoplasm, or the nucleus, respectively. When a DNA topoisomerase inhibitor is delivered into the nucleus by a neutral and lipophilic PCC, the anticancer efficacy is dramatically improved. The findings shed light to tune the interactions at the “bio‐nano” interface. This study provides a key strategy for future work in targeting specific cell organelles for cell imaging, cargo delivery, and therapy. This research also offers key insight into the engineering of nanoscopic materials for furnishing cell organelle‐specificity.