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Ag + ‐Gated Surface Chemistry of Gold Nanoparticles and Colorimetric Detection of Acetylcholinesterase
Author(s) -
Zhang Jiangjiang,
Zheng Wenshu,
Jiang Xingyu
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201801680
Subject(s) - colloidal gold , chemistry , bromide , nanomaterials , ascorbic acid , combinatorial chemistry , peroxidase , selectivity , nanoparticle , analyte , biosensor , membrane , nanotechnology , inorganic chemistry , organic chemistry , catalysis , enzyme , materials science , chromatography , biochemistry , food science
Chemical regulation of enzyme‐mimic activity of nanomaterials is challenging because it requires a precise understanding of the surface chemistry and mechanism, and rationally designed applications. Herein, Ag + ‐gated peroxidase activity is demonstrated by successfully modulating surface chemistry of cetyltrimethylammonium bromide‐capped gold nanoparticles (CTAB‐AuNPs). A surface blocking effect of long‐chain molecules on surfaces of AuNPs that inhibit peroxidase activity of AuNPs is found. Ag + ions can selectively bind on the surfaces of AuNPs and competitively destroy CTAB membrane forming Ag + @CTAB‐AuNPs complexes to result in enhanced peroxidase activity. Ag + @CTAB‐AuNPs show the highest peroxidase activity compared to similar‐sized citrate‐capped and ascorbic acid‐capped AuNPs. Ag + @CTAB‐AuNPs can potentially develop into analyte‐responsive systems and exhibit advantages in the optical sensing field. For example, the Ag + @CTAB‐AuNPs system shows an enhanced sensitivity and selectivity for acetylcholinesterase activity sensing compared to other methods.