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Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery
Author(s) -
Hu Xinghao,
Lim Byeonghwa,
Torati Sri Ramulu,
Ding Junjia,
Novosad Valentine,
Im MiYoung,
Reddy Venu,
Kim Kunwoo,
Jung Eunjoo,
Shawl Asif Iqbal,
Kim Eunjoo,
Kim CheolGi
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201800504
Subject(s) - biomolecule , nanotechnology , biochip , microfluidics , digital microfluidics , magnetic nanoparticles , materials science , multiplexing , computer science , optoelectronics , nanoparticle , electrowetting , telecommunications , dielectric
The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on‐chip separation and trapping, still remain challenging. Here, a universal micromagnet junction for self‐navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein‐functionalized carriers in high resolution, as well as MCF‐7 and THP‐1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next‐generation biochips.