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Injectable Hydrogels: An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells (Small 36/2017)
Author(s) -
OmidiniaAnarkoli Abdolrahman,
Boesveld Sarah,
Tuvshindorj Urandelger,
Rose Jonas C.,
Haraszti Tamás,
De Laporte Laura
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770191
Subject(s) - self healing hydrogels , electrospinning , materials science , nanotechnology , matrix (chemical analysis) , nanofiber , tissue engineering , anisotropy , biomedical engineering , polymer , composite material , polymer chemistry , medicine , physics , quantum mechanics
In article number 1702207 , Laura De Laporte and co‐workers report a novel anisotropic injectable hydrogel that promotes unidirectional nerve growth in a 3D microenvironment. The hybrid hydrogel comprises short magneto‐responsive fibers, which are produced via an electrospinning/cryocutting method. After injection, they orient in a low external magnetic field, while the hydrogel crosslinks to fix the direction of the matrix. The grown nerves are functional with spontaneous electrical activity parallel to the direction of the fibers.