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Organ‐On‐A‐Chip: Biomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model (Small 15/2017)
Author(s) -
Ribas João,
Zhang Yu Shrike,
Pitrez Patrícia R.,
Leijten Jeroen,
Miscuglio Mario,
Rouwkema Jeroen,
Dokmeci Mehmet Remzi,
Nissan Xavier,
Ferreira Lino,
Khademhosseini Ali
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770087
Subject(s) - progeria , inflammation , strain (injury) , disease , medicine , biology , genetics , gene
A progeria‐on‐a‐chip is developed to recapitulate the biomechanical dynamics of vascular disease and aging, shown in article number 1603737, by Lino Ferreira, Ali Khademhosseini, and co‐workers. The model stretches vascular smooth muscle cells and shows an exacerbated inflammation and DNA damage. The progeria‐on‐a‐chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.