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Carbon Nanotubes: Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal‐of‐Entry (Small 15/2017)
Author(s) -
Ma Juan,
Li Ruibin,
Liu Yin,
Qu Guangbo,
Liu Jing,
Guo Wenli,
Song Haoyang,
Li Xinghong,
Liu Yajun,
Xia Tian,
Yan Bing,
Liu Sijin
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770084
Subject(s) - inflammation , hepcidin , iron homeostasis , carbon nanotube , homeostasis , anemia , immunology , microbiology and biotechnology , chemistry , nanotechnology , medicine , materials science , biology , biochemistry , metabolism
In article number 1603830, by Sijin Liu and co‐workers, the exposure of multi‐wall carbon nanotubes (MWCNTs) alters hepatic hepcidin‐mediated systemic iron homeostasis through pro‐inflammatory responses in mice, leading to limited iron availability for red blood cell formation, and eventually the development of anemia of inflammation. This study opens a new path to understanding the biological impacts of carbon nanotubes through their secondary or compensatory effects beyond the primary target tissues and organs.