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Gold Nanoparticles: Interference‐Free Surface‐Enhanced Raman Scattering Tags for Single‐Cell Molecular Imaging with a High Signal‐to‐Background Ratio (Small 15/2017)
Author(s) -
Ma Sisi,
Li Qiang,
Yin Yongmei,
Yang Jie,
Liu Dingbin
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770083
Subject(s) - raman scattering , raman spectroscopy , interference (communication) , materials science , colloidal gold , nanoparticle , degradation (telecommunications) , signal (programming language) , nanotechnology , optoelectronics , analytical chemistry (journal) , optics , chemistry , physics , computer science , chromatography , telecommunications , channel (broadcasting) , programming language
In article number 1603340, by Dingbin Liu and co‐workers, an interference‐free surface‐enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single‐cell level. The Raman tags present a strong and sharp peak in the cellular Raman‐silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in layered gold nanoparticles, avoiding desorption and enzymatic degradation in physiological conditions.