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Drug Delivery: One‐Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid‐Switchable Surface Charge for Overcoming Drug Resistance (Small 9/2017)
Author(s) -
Feng Qiang,
Liu Jianping,
Li Xuanyu,
Chen Qinghua,
Sun Jiashu,
Shi Xinghua,
Ding Baoquan,
Yu Haijun,
Li Yaping,
Jiang Xingyu
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770053
Subject(s) - drug , micelle , microfluidics , surface modification , drug delivery , materials science , nanotechnology , rigidity (electromagnetism) , surface charge , biophysics , combinatorial chemistry , chemistry , organic chemistry , pharmacology , medicine , composite material , aqueous solution , biology
In article number 1603109, Jiashu Sun, Haijun Yu, Xingyu Jiang, and co‐workers utilize microfluidic chips to generate rigid pH‐sensitive micellar nanocomplex (RPN) with tunable rigidity and acid‐switchable surface charge for overcoming cancer drug resistance. The functionalization of RPN is realized through the incorporation of rigid PLGA core into pH‐sensitive micelle. The RPN significantly enhances therapeutic efficacy against MCF‐7/ADR xenograft tumor in mice, without the assistance of other therapeutic means