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Cancer Multidrug Resistance: Safe and Effective Reversal of Cancer Multidrug Resistance Using Sericin‐Coated Mesoporous Silica Nanoparticles for Lysosome‐Targeting Delivery in Mice (Small 9/2017)
Author(s) -
Liu Jia,
Li Qilin,
Zhang Jinxiang,
Huang Lei,
Qi Chao,
Xu Luming,
Liu Xingxin,
Wang Guobin,
Wang Lin,
Wang Zheng
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770049
Subject(s) - lysosome , mesoporous silica , multiple drug resistance , drug delivery , efflux , doxorubicin , nanoparticle , materials science , cancer cell , nanotechnology , drug resistance , cancer , pharmacology , chemistry , mesoporous material , medicine , chemotherapy , biochemistry , biology , microbiology and biotechnology , enzyme , catalysis
Sericin‐wrapped mesoporous silica nanoparticles (SMSNs) with pH and protease dual responsiveness are successfully fabricated as a lysosome‐targeting drug delivery system by Guobin Wang, Lin Wang, Zheng Wang, and co‐workers in article number 1602567. Such a dual responsive system offers a rapid doxorubicin release in lysosomes, which bypasses the membrane pump mediated drug efflux, thereby achieving the reversal of drug resistance.