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Peptoids: Antiamyloidogenic Activity of Aβ42‐Binding Peptoid in Modulating Amyloid Oligomerization (Small 1/2017)
Author(s) -
Zhao Zijian,
Zhu Ling,
Li Haiyun,
Cheng Peng,
Peng Jiaxi,
Yin Yudan,
Yang Yang,
Wang Chen,
Hu Zhiyuan,
Yang Yanlian
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201770002
Subject(s) - peptoid , cytotoxicity , oligomer , chemistry , inhibitory postsynaptic potential , amyloid β , amyloid (mycology) , membrane permeability , fibrillation , permeability (electromagnetism) , biophysics , membrane , combinatorial chemistry , biochemistry , peptide , in vitro , medicine , disease , biology , organic chemistry , inorganic chemistry , atrial fibrillation
Antiamyloidogenic agents have promising application potential in AD therapies. In article number 1602857, L. Zhu, Z. Hu, Y. Yang, and co‐workers present an Aβ42‐binding agent amyloid inhibitory 1 (AIP1), demonstrate its inhibitory effect on Aβ42 oligomerization and fibrillation, and show that AIP1 rescue Aβ42‐induced cytotoxicity through decreasing Aβ42 oligomer content is related to cell membrane permeability.