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Interfacial Engineering of Hierarchical Transition Metal Oxide Heterostructures for Highly Sensitive Sensing of Hydrogen Peroxide
Author(s) -
Zhang Wen,
Fan Guozheng,
Yi Huan,
Jia Gan,
Li Zhaosheng,
Yuan Chunwei,
Bai Yunfei,
Fu Degang
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201703713
Subject(s) - high resolution transmission electron microscopy , heterojunction , materials science , x ray photoelectron spectroscopy , nanostructure , oxide , hydrogen peroxide , electron transfer , nanotechnology , chemical engineering , transmission electron microscopy , photochemistry , chemistry , optoelectronics , organic chemistry , engineering , metallurgy
Hydrogen peroxide (H 2 O 2 ) is a major messenger molecule in cellular signal transduction. Direct detection of H 2 O 2 in complex environments provides the capability to illuminate its various biological functions. With this in mind, a novel electrochemical approach is here proposed by integrating a series of CoO nanostructures on CuO backbone at electrode interfaces. High‐resolution transmission electron microscopy (HRTEM), X‐ray diffraction, and X‐ray photoelectron spectroscopy demonstrate successful formation of core–shell CuO–CoO hetero‐nanostructures. Theoretical calculations further confirm energy‐favorable adsorption of H 2 O 2 on surface sites of CuO–CoO heterostructures. Contributing to the efficient electron transfer path and enhanced capture of H 2 O 2 in the unique leaf‐like CuO–CoO hierarchical 3D interface, an optimal biosensor‐based CuO–CoO‐2.5 h electrode exhibits an ultrahigh sensitivity (6349 µA m m −1 cm −2 ), excellent selectivity, and a wide detection range for H 2 O 2 , and is capable of monitoring endogenous H 2 O 2 derived from human lung carcinoma cells A549. The synergistic effects for enhanced H 2 O 2 adsorption in integrated CuO–CoO nanostructures and performance of the sensor suggest a potential for exploring pathological and physiological roles of reactive oxygen species like H 2 O 2 in biological systems.