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Super‐Absorbent Polymer Valves and Colorimetric Chemistries for Time‐Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin‐Mounted Soft Microfluidics
Author(s) -
Kim Sung Bong,
Zhang Yi,
Won Sang Min,
Bandodkar Amay J.,
Sekine Yurina,
Xue Yeguang,
Koo Jahyun,
Harshman Sean W.,
Martin Jennifer A.,
Park Jeong Min,
Ray Tyler R.,
Crawford Kaitlyn E.,
Lee KyuTae,
Choi Jungil,
Pitsch Rhonda L.,
Grigsby Claude C.,
Strang Adam J.,
Chen YuYu,
Xu Shuai,
Kim Jeonghyun,
Koh Ahyeon,
Ha Jeong Sook,
Huang Yonggang,
Kim Seung Wook,
Rogers John A.
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201703334
Subject(s) - microfluidics , polymer , reagent , materials science , nanotechnology , computer science , biomedical engineering , chemistry , composite material , organic chemistry , engineering
This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin‐mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well‐defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.