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Focused Ultrasound Enabled Trans‐Blood Brain Barrier Delivery of Gold Nanoclusters: Effect of Surface Charges and Quantification Using Positron Emission Tomography
Author(s) -
Sultan Deborah,
Ye Dezhuang,
Heo Gyu Seong,
Zhang Xiaohui,
Luehmann Hannah,
Yue Yimei,
Detering Lisa,
Komarov Sergey,
Taylor Sara,
Tai YuanChuan,
Rubin Joshua B.,
Chen Hong,
Liu Yongjian
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201703115
Subject(s) - nanoclusters , positron emission tomography , biodistribution , materials science , biomedical engineering , nanotechnology , drug delivery , positron , blood–brain barrier , pet imaging , in vivo , nuclear medicine , medicine , central nervous system , physics , microbiology and biotechnology , quantum mechanics , biology , electron
Focused ultrasound (FUS) technology is reported to enhance the delivery of 64 Cu‐integrated ultrasmall gold nanoclusters ( 64 Cu‐AuNCs) across the blood‐brain barrier (BBB) as measured by positron emission tomography (PET). To better define the optimal physical properties for brain delivery, 64 Cu‐AuNCs with different surface charges are synthesized and characterized. In vivo biodistribution studies are performed to compare the individual organ uptake of each type of 64 Cu‐AuNCs. Quantitative PET imaging post‐FUS treatment shows site‐targeted brain penetration, retention, and diffusion of the negative, neutral, and positive 64 Cu‐AuNCs. Autoradiography is performed to compare the intrabrain distribution of these nanoclusters. PET Imaging demonstrates the effective BBB opening and successful delivery of 64 Cu‐AuNCs into the brain. Of the three 64 Cu‐AuNCs investigated, the neutrally charged nanostructure performs the best and is the candidate platform for future theranostic applications in neuro‐oncology.