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Black Phosphorus Quantum Dots with Renal Clearance Property for Efficient Photodynamic Therapy
Author(s) -
Guo Tao,
Wu Ying,
Lin Yan,
Xu Xin,
Lian Hao,
Huang Guoming,
Liu JiZan,
Wu Xiaoping,
Yang HuangHao
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201702815
Subject(s) - black phosphorus , photodynamic therapy , nanomedicine , quantum dot , biocompatible material , nanomaterials , in vivo , materials science , photothermal therapy , nanotechnology , irradiation , cytotoxicity , biophysics , nanoparticle , biomedical engineering , in vitro , chemistry , optoelectronics , medicine , biochemistry , physics , microbiology and biotechnology , organic chemistry , nuclear physics , biology
Black phosphorus (BP) nanomaterials have emerged as rapidly rising stars in the field of nanomedicine. In this work, BP quantum dots (BPQDs) are synthesized and their potential as photosensitizers is investigated for the first time. The BPQDs present good stability in physiological medium and no appreciable cytotoxicity. More importantly, the BPQDs can be rapidly eliminated from the body in their intact form via renal clearance due to their ultrasmall hydrodynamic diameter (5.4 nm). Both in vitro and in vivo studies indicate that the BPQDs have excellent photodynamic effect under light irradiation that can effectively generate reactive oxygen species to kill cancer cells. The BPQDs thus can serve as biocompatible and powerful photosensitizers for efficient photodynamic therapy.