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Metal–Organic Framework Encapsulation for the Preservation and Photothermal Enhancement of Enzyme Activity
Author(s) -
Tadepalli Sirimuvva,
Yim Jieun,
Cao Sisi,
Wang Zheyu,
Naik Rajesh R.,
Singamaneni Srikanth
Publication year - 2018
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201702382
Subject(s) - photothermal therapy , biomolecule , nanotechnology , materials science , nanostructure , plasmon , enzyme , biomineralization , photothermal effect , chemistry , chemical engineering , biochemistry , optoelectronics , engineering
Interfacing biomolecules with functional materials is a key strategy toward achieving externally‐triggered biological function. The rational integration of functional proteins, such as enzymes, with plasmonic nanostructures that exhibit unique optical properties such as photothermal effect provides a means to externally control the enzyme activity. However, due to the labile nature of enzymes, the photothermal effect of plasmonic nanostructures is mostly utilized for the enhancement of the biocatalytic activity of thermophilic enzymes. In order to extend and utilize the photothermal effect to a broader class of enzymes, a means to stabilize the immobilized active protein is essential. Inspired by biomineralization for the encapsulation of soft tissue within protective exteriors in nature, metal–organic framework is utilized to stabilize the enzyme. This strategy provides an effective route to enhance and externally modulate the biocatalytic activity of enzymes bound to functional nanostructures over a broad range of operating environments that are otherwise hostile to the biomolecules.