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The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo
Author(s) -
Liu Ye,
Workalemahu Bereket,
Jiang Xingyu
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201701815
Subject(s) - in vivo , in vitro , nanomaterials , nanotechnology , chemistry , biophysics , microbiology and biotechnology , materials science , biology , biochemistry
Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of NMs cellular uptake between in vitro and in vivo, a focus on reviewing recent works about the effects of four physicochemical parameters of NMs (size, rigidity, shape, surface modification) on regulating NMs cellular uptake in vitro and in vivo is undertaken. This review can provide readers some useful clues and new thinking for understanding NMs cellular uptake in depth.