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Dual‐Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O 2 Self‐Sufficient Nanoplatform
Author(s) -
Liu LiHan,
Zhang YaoHui,
Qiu WenXiu,
Zhang Lu,
Gao Fan,
Li Bin,
Xu Lu,
Fan JinXian,
Li ZiHao,
Zhang XianZheng
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201701621
Subject(s) - photodynamic therapy , photosensitizer , cancer research , in vivo , tumor hypoxia , liposome , tumor microenvironment , hypoxia (environmental) , lipid peroxidation , chemistry , irradiation , biophysics , metastasis , materials science , radiation therapy , medicine , nanotechnology , tumor cells , oxygen , biology , biochemistry , photochemistry , oxidative stress , cancer , microbiology and biotechnology , organic chemistry , physics , nuclear physics
Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome‐based nanoparticle (designated as LipoMB/CaO 2 ) with O 2 self‐sufficient property for dual‐stage light‐driven PDT is demonstrated to address this problem. Through a short time irradiation, 1 O 2 activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO 2 with H 2 O, resulting in accelerated O 2 production. Accelerated O 2 level further regulates hypoxic tumor microenvironment and in turn improves 1 O 2 generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO 2 to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side‐effect. The O 2 self‐sufficient LipoMB/CaO 2 nanoplatform with dual‐stage light manipulation is a successful attempt for PDT against hypoxic tumor.