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Hydrogen Polysulfide Biosignal‐Responsive Polymersomes as a Nanoplatform for Distinguishing Intracellular Reactive Sulfur Species (RSS)
Author(s) -
Zhang Jian,
Hao Xiang,
Sang Wei,
Yan Qiang
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201701601
Subject(s) - polysulfide , intracellular , rss , polymersome , chemistry , sulfur , biophysics , microbiology and biotechnology , polymer , biochemistry , biology , copolymer , computer science , electrolyte , organic chemistry , electrode , amphiphile , operating system
Reactive sulfur species (RSS) are a family of crucial biosignals for regulating cell processes. Among these, hydrogen polysulfide (H 2 S n , n ≥ 2) is a hallmark of tumor suppressor activation and regarded as the actual regulator to mediate sulfur‐related biology. However, high effective recognition of intracellular H 2 S n is insurmountable due to its extremely low concentration and the disturbance of RSS analogues. Here an H 2 S n ‐responsive macromolecule that can distinguish H 2 S n from intracellular RSS through polymer degradation in ultrasensitive and highly selective manner is reported. This kind of polymers can further self‐assemble into vesicular nanostructure. Upon cell uptake, they can be function as “all‐in‐one” H 2 S n ‐nanoplatforms, in order to fulfill multiple ambitious tasks including monitoring the H 2 S n biosynthetic pathways, unraveling the puzzles of H 2 S n ‐mediated cellular events, and conducting H 2 S n pathological milieu‐specific drug delivery.