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Novel Magnetic‐Luminescent Janus Nanoparticles for Cell Labeling and Tumor Photothermal Therapy
Author(s) -
Wu Qiang,
Lin Yining,
Wo Fangjie,
Yuan Yufeng,
Ouyang Qingling,
Song Jun,
Qu Junle,
Yong KenTye
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201701129
Subject(s) - materials science , photothermal therapy , luminescence , nanoparticle , nanomedicine , nanotechnology , cancer cell , biophysics , cancer , medicine , optoelectronics , biology
Abstract Magnetic‐luminescent nanocomposites have multiple uses including multimodal imaging, magnetic targeted drug delivery, and cancer imaging‐guided therapies. In this work, dumbbell‐like MnFe 2 O 4 –NaYF 4 Janus nanoparticles are synthesized via a two‐step thermolysis approach. These synthesized nanoparticles exhibit stability in aqueous solutions and very low cytotoxicity after poly(acryl amide) modification. High cellular uptake efficiency is observed for the folic acid‐conjugated MnFe 2 O 4 –NaYF 4 in human esophagus carcinoma cells (Eca‐109) due to the upconversion luminescence properties as well as the folate targeting potential. The MnFe 2 O 4 –NaYF 4 also strongly absorbs light in the near‐infrared range and rapidly converts to heat energy. It is demonstrated that Eca‐109 cells incubated with MnFe 2 O 4 –NaYF 4 are killed with high efficiency after 808 nm laser irradiation. Furthermore, the growth of tumors in mice (grown from Eca‐109 cells) is highly inhibited by the photothermal effects of MnFe 2 O 4 –NaYF 4 efficiently. Histological analysis reveals no pathological change and inflammatory response in heart, liver, spleen, lung, or kidney. The low toxicity, excellent luminescence, and highly efficient photothermal therapy properties of MnFe 2 O 4 –NaYF 4 Janus nanoparticles illustrated in this work support their vast potential for nanomedicine and cancer therapy.