Premium
A DNA Origami Mechanical Device for the Regulation of Microcosmic Structural Rigidity
Author(s) -
Wan Neng,
Hong Zhouping,
Wang Huading,
Fu Xin,
Zhang Ziyue,
Li Chao,
Xia Han,
Fang Yan,
Li Maoteng,
Zhan Yi,
Yang Xiangliang
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201700866
Subject(s) - dna origami , structural rigidity , rigidity (electromagnetism) , nanotechnology , dna , materials science , liposome , nanostructure , dna nanotechnology , biophysics , chemistry , composite material , structural engineering , engineering , biochemistry , biology
DNA origami makes it feasible to fabricate a tremendous number of DNA nanostructures with various geometries, dimensions, and functionalities. Moreover, an increasing amount of research on DNA nanostructures is focused on biological and biomedical applications. Here, the reversible regulation of microcosmic structural rigidity is accomplished using a DNA origami device in vitro. The designed DNA origami monomer is composed of an internal central axis and an external sliding tube. Due to the external tube sliding, the device transforms between flexible and rigid states. By transporting the device into the liposome, the conformational change of the origami device induces a structural change in the liposome. The results obtained demonstrate that the programmed DNA origami device can be applied to regulate the microcosmic structural rigidity of liposomes. Because microcosmic structural rigidity is important to cell proliferation and function, the results obtained potentially provide a foundation for the regulation of cell microcosmic structural rigidity using DNA nanostructures.