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Nanofabrication: Controllable Large‐Scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform (Small 43/2016)
Author(s) -
Chang Lingqian,
GallegoPerez Daniel,
Chiang ChiLing,
Bertani Paul,
Kuang Tairong,
Sheng Yan,
Chen Feng,
Chen Zhou,
Shi Junfeng,
Yang Hao,
Huang Xiaomeng,
Malkoc Veysi,
Lu Wu,
Lee Ly James
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670222
Subject(s) - nanotechnology , nanoelectromechanical systems , nanolithography , transfection , materials science , silicon , optoelectronics , chemistry , fabrication , gene , nanomedicine , nanoparticle , medicine , alternative medicine , pathology , biochemistry
On page 5971, D. Gallego‐Perez, W. Lu, L. J. Lee, and co‐workers report an advanced Bio‐NEMS (nanoelectromechanical system) device for high‐throughput cell trapping and gene delivery on a silicon‐nanochannel array chip. With a thin‐film hydrodynamic approach, individual cells are precisely positioned on a nanochannel array where the molecules of well‐controlled dose are delivered into each cells. The device shows potential for transfection of electrogenic cells, gene therapy, and living cell interrogation.