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Cellular Uptake: Size‐Dependent Cellular Uptake of DNA Functionalized Gold Nanoparticles (Small 40/2016)
Author(s) -
Wong Alexis C.,
Wright David W.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670207
Subject(s) - colloidal gold , dna , nanoparticle , transfection , intracellular , biophysics , nanotechnology , chemistry , materials science , microbiology and biotechnology , biochemistry , biology , gene
On page 5592, A. C. Wong and D. W. Wright demonstrate that cells internalize small DNA functionalized gold nanoparticles (DNA‐AuNPs) in higher amounts than large DNA‐AuNPs. DNA conformation, DNA density, and surface charge do not reliably predict nanoparticle accumulation in cells. These results inform the design of intracellular DNA‐AuNP probes that have enhanced cellular transfection.