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Chemotherapy: Amino Acid Metabolism Abnormity and Microenvironment Variation Mediated Targeting and Controlled Glioma Chemotherapy (Small 40/2016)
Author(s) -
An Sai,
Lu Xiuhong,
Zhao Weili,
Sun Tao,
Zhang Yu,
Lu Yifei,
Jiang Chen
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670205
Subject(s) - glioma , amino acid , chemotherapy , transporter , metabolism , tumor microenvironment , brain tumor , cancer research , chemistry , tumor cells , biochemistry , microbiology and biotechnology , pharmacology , biophysics , medicine , biology , pathology , gene
The brain requires large amounts of amino acids, which normally get across the brain capillaries through transporters and are then used by brain cells. When glioma takes place, tumor cells sitting right outside brain capillaries are always ready to grab the food of brain cells. Based on this, on page 5633, C. Jiang and co‐workers decorate therapeutic nanoparticles with amino acid derivates, making them act as stealth nanoparticles to be swallowed by tumor cells for glioma therapy.