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Nanomaterial Uptake: Fast Targeting and Cancer Cell Uptake of Luminescent Antibody‐Nanozeolite Bioconjugates (Small 39/2016)
Author(s) -
Marega Riccardo,
Prasetyanto Eko Adi,
Michiels Carine,
De Cola Luisa,
Bonifazi Davide
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670198
Subject(s) - internalization , endocytosis , cetuximab , nanomaterials , biodistribution , cancer cell , chemistry , cancer , nanotechnology , antibody , cancer research , cell , biophysics , materials science , medicine , in vitro , biochemistry , monoclonal antibody , immunology , biology
On page 5431, L. De Cola, D. Bonifazi, and co‐workers report the fast targeting and cancer cells uptake of nanozeolite/Cetuximab bioconjugates. The effects are depicted on the front cover, which highlights the antibody‐dependent and receptor‐mediated endocytosis of this luminescent nanomaterial by the cancer cells. This hasty internalization profile can be exploited to reduce the nanomaterial clearance processes occurring in‐vivo, which determine unfavourable biodistribution and foster “off‐target” activities.