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RNA Detection: Gold‐Quantum Dot Core–Satellite Assemblies for Lighting Up MicroRNA In Vitro and In Vivo (Small 34/2016)
Author(s) -
Zhao Xueli,
Xu Liguang,
Sun Maozhong,
Ma Wei,
Wu Xiaoling,
Kuang Hua,
Wang Libing,
Xu Chuanlai
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670168
Subject(s) - quantum dot , fluorescence , satellite , core (optical fiber) , dna , nanotechnology , in vivo , rna , microrna , materials science , optoelectronics , physics , gene , optics , biology , genetics , astronomy , composite material
On page 4662, a core‐satellite structure was fabricated by H. Kuang and co‐workers using partly‐complementary‐DNA‐functionalized Au NPs of 35 ± 2 nm and quantum dots (QDs) of 6 ± 1 nm. The fluorescence of the QD satellites was quenched after assembly with the Au core. In the presence of the target miR, the hairpin sequence of the core‐satellite assembly was destroyed by DNA hybridization, leading to the restoration of fluorescence.