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Biomaterials: Multifunctional Transmembrane Protein Ligands for Cell‐Specific Targeting of Plasma Membrane‐Derived Vesicles (Small 28/2016)
Author(s) -
Zhao Chi,
Busch David J.,
Vershel Connor P.,
Stachowiak Jeanne C.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670136
Subject(s) - transmembrane protein , vesicle , membrane protein , membrane , microbiology and biotechnology , fluorophore , cell , chemistry , biophysics , cell membrane , ligand (biochemistry) , transmembrane domain , receptor , biochemistry , biology , fluorescence , physics , quantum mechanics
Cell‐derived plasma membrane vesicles extracted from genetically engineered donor cells can selectively target cells based on their receptor expression profiles, as demonstrated by J. C. Stachowiak and co‐workers on page 3837. These engineered donor cells have a stable expression of transmembrane protein ligands that contain multiple domains, including a targeting ligand, a spacer and a fluorophore.