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Intracellular Delivery: Redox‐Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap‐Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016)
Author(s) -
Lee BaiYu,
Li Zilu,
Clemens Daniel L.,
Dillon Barbara Jane,
Hwang Angela A.,
Zink Jeffrey I.,
Horwitz Marcus A.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670134
Subject(s) - mesoporous silica , intracellular , redox , chemistry , snap , nanoparticle , drug delivery , biophysics , mesoporous material , nanotechnology , materials science , combinatorial chemistry , biochemistry , organic chemistry , biology , catalysis , computer graphics (images) , computer science
The drug trapping and intracellular release mechanism of redox‐responsive disulfide snap‐top mesoporous silica nanoparticles (MSN‐SS‐MXF) is depicted by J. I. Zink, M. A. Horwitz and co‐workers on page 3690. Mesoporous silica nanoparticles with antibiotic (cyan) trapped within their pores by disulfide snap‐tops are avidly ingested by macrophages. The intracellular redox potential reduces the disulfide (yellow) in the stalk (green/blue), releases the caps (orange) and frees drug to kill Francisella tularensis (green). Artwork by Bastian Ruehle.