Premium
siRNA Delivery: Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016)
Author(s) -
Chen Chao,
Posocco Paola,
Liu Xiaoxuan,
Cheng Qiang,
Laurini Erik,
Zhou Jiehua,
Liu Cheng,
Wang Yang,
Tang Jingjie,
Col Valentina Dal,
Yu Tianzhu,
Giorgio Suzanne,
Fermeglia Maurizio,
Qu Fanqi,
Liang Zicai,
Rossi John J.,
Liu Minghua,
Rocchi Palma,
Pricl Sabrina,
Peng Ling
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670131
Subject(s) - dendrimer , amphiphile , gene silencing , gene delivery , supramolecular chemistry , nanotechnology , drug delivery , chemistry , materials science , genetic enhancement , organic chemistry , polymer , biochemistry , molecule , gene , copolymer
Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high‐generation dendrimers for siRNA delivery, as presented by S. Pricl, L. Peng, and co‐workers on page 3667. An optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion is crucial for self‐assembly of these amphiphilic dendrons into micellar nanostructures, and critically impacts the effectiveness of siRNA delivery and functional gene silencing.