Premium
Silica Nanospheres: Hollow Structure Improved Anti‐Cancer Immunity of Mesoporous Silica Nanospheres In Vivo (Small 26/2016)
Author(s) -
Wang Xiupeng,
Li Xia,
Ito Atsuo,
Yoshiyuki Kazuko,
Sogo Yu,
Watanabe Yohei,
Yamazaki Atsushi,
Ohno Tadao,
Tsuji Noriko M.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670129
Subject(s) - in vivo , mesoporous silica , mesoporous material , materials science , nanotechnology , in vitro , cancer cell , splenocyte , immunity , cancer , biophysics , chemistry , immune system , immunology , catalysis , biochemistry , biology , genetics , microbiology and biotechnology
Hollow and non‐hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants by X. Wang, A. Ito, N. M. Tsuji, and co‐workers on page 3510. The hollow structure of mesoporous silica nanospheres significantly promotes cellular uptake of a model cancer antigen by macrophage‐like cells in vitro, improves anti‐cancer immunity, and increases CD4+ and CD8+ T cell populations in splenocytes of mice in vivo.