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Tissue Engineering: Advancing Tissue Engineering: A Tale of Nano‐, Micro‐, and Macroscale Integration (Small 16/2016)
Author(s) -
Leijten Jeroen,
Rouwkema Jeroen,
Zhang Yu Shrike,
Nasajpour Amir,
Dokmeci Mehmet Remzi,
Khademhosseini Ali
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670079
Subject(s) - tissue engineering , nano , nanotechnology , hard tissue , materials science , macro , angiogenesis , neurogenesis , computer science , biomedical engineering , engineering , biology , microbiology and biotechnology , composite material , dentistry , medicine , cancer research , programming language
Micromaterials can be fabricated in a near infinite number of shapes, sizes, and chemical compositions. These micromaterials can subsequently be assembled into macro‐sized constructs using bottom‐up approaches as reviewed by A. Khademhosseini and co‐workers on page 2130. Each type of micromaterial can provide a unique micro‐environment to the (stem) cells. This can be leveraged to drive e.g., angiogenesis, neurogenesis, or osteogenesis in a spatially preprogrammed manner to allow the formation of organized bioengineered tissues.