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Nanomedicine: Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo (Small 14/2016)
Author(s) -
Rehberg Markus,
Nekolla Katharina,
Sellner Sabine,
Praetner Marc,
Mildner Karina,
Zeuschner Dagmar,
Krombach Fritz
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670068
Subject(s) - nanomedicine , nanomaterials , drug delivery , membrane , in vivo , intracellular , nanotechnology , materials science , nanotoxicology , nanoparticle , biophysics , microbiology and biotechnology , chemistry , biology , biochemistry
Cellular uptake of nanomaterials from the bloodstream and their subsequent distribution in tissue is a crucial step for diverse drug delivery approaches. On page 1882, M. Rehberg and co‐workers describe the presence of microtubule‐containing membrane nanotubes connecting perivascular and tissue‐resident macrophages in skeletal muscle tissue. Perivascular macrophages are able to sample nanoparticles from the blood stream, which are then actively transported in the muscle within membrane nanotubes.