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Tissue Engineering: Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake (Small 11/2016)
Author(s) -
Minardi Silvia,
Corradetti Bruna,
Taraballi Francesca,
Sandri Monica,
Martinez Jonathan O.,
Powell Sebastian T.,
Tampieri Anna,
Weiner Bradley K.,
Tasciotti Ennio
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670055
Subject(s) - scaffold , plga , microsphere , drug delivery , payload (computing) , tissue engineering , biomedical engineering , nanotechnology , materials science , chemistry , nanoparticle , computer science , chemical engineering , medicine , engineering , computer network , network packet
Avoiding the clearance of drug delivery systems from 3D scaffolds is crucial to preserve the bioactivity of their therapeutic payload. This is accomplished on page 1479, by E. Tasciotti and co‐workers, through a “concealing” strategy: cloaking PLGA microspheres with the type I collagen matrix of a biomimetic scaffold, which enables the control of the production of inflammatory mediators.