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Micelles: Rod‐to‐Globule Transition of pDNA/PEG–Poly( l ‐Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness (Small 9/2016)
Author(s) -
Tockary Theofilus A.,
Osada Kensuke,
Motoda Yusuke,
Hiki Shigehiro,
Chen Qixian,
Takeda Kaori M.,
Dirisala Anjaneyulu,
Osawa Shigehito,
Kataoka Kazunori
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670048
Subject(s) - micelle , peg ratio , biophysics , rigidity (electromagnetism) , dna , lysine , chemical engineering , materials science , chemistry , nanotechnology , biochemistry , organic chemistry , biology , amino acid , composite material , aqueous solution , engineering , economics , finance
Upon PEG removal, the change of rod shapes into globule shapes is observed for packaged DNA in polyplex micelles that are prepared from block copolymers with acid‐labile linkage between the PEG and poly(L‐lysine) (PLys). On page 1193, K. Osada, K. Kataoka, and co‐workers use the details of this transition behavior to elucidate the essential regulating factors of polyplex micelle structures, in order to find their structure–function relationship and promote their utilization as a gene delivery system.