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Microfluidics: Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform (Small 5/2016)
Author(s) -
Uzel Sebastien G. M.,
Amadi Ovid C.,
Pearl Taylor M.,
Lee Richard T.,
So Peter T. C.,
Kamm Roger D.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201670025
Subject(s) - microfluidics , concentration gradient , extracellular matrix , chemotaxis , biological system , cell culture , extracellular , biophysics , materials science , nanotechnology , chemistry , microbiology and biotechnology , biology , chromatography , biochemistry , receptor , genetics
The microfluidic designed by R. D. Kamm and co‐workers allow the formation of simultaneous or sequential concentration gradients within a 3D extracellular matrix. On page 612, these gradients can be used to investigate biological phenomena, such as the differentiation of progenitor cells into neurons as it occurs within the developing spinal cord, or the dynamics of chemotaxis when cells are exposed to time‐dependent concentration profiles.